January 14, 2020

This new paper provide the first brain map of alcohol dependence at single cell resolution in an animal model of Alcohol use disorder.

Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of Califo...

January 14, 2020

This paper provide preclinical evidence that targeting the D3 receptors may provide efficacy in the treatment of opioid use disorder.

Using an animal model for the study of opioid use disorder, researchers at University of California San Diego School of Medicine report...

January 13, 2020

This new paper identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates that it is possible to reverse the motivation to use opioids in opioid-dependent rats.

More than 2 million indivi...

March 26, 2019

This new paper identify a key brain network responsible for alcohol dependence and demonstrates that it is possible to reverse the desire to drink in alcohol-dependent rats by targeting this specific group of neurons using lasers.

In a new study published...

October 17, 2018

The George lab demonstrates that a novel enzymatic approach that prevents nicotine from reaching the brain not only decrease the level of nicotine dependence, but also decreases compulsive nicotine intake and relapse in animal models.

In a study published online in Scie...

October 14, 2018

The George lab identified the orphan receptor GPR139 as a potential target for the treatment of compulsive alcohol drinking and hyperalgesia during alcohol withdrawal.

This study, lead by Dr. Jenni Kononoff provides 

robust preclinical evide...

July 5, 2018

The George lab, in collaboration with multiple research groups, published several studies that identify key brain mechanisms responsible for drug and nicotine addiction.

These studies 1) provide robust preclinical evidence fort the efficacy of deep brain stimu...

July 5, 2018

Dr. de Guglielmo from the George lab published a new study in collaboration with the Palmer lab (UCSD) that provide robust preclinical evidence that a novel compound called pBBG is more effective in reducing alcohol intake in dependent rats than in nondepende...

July 2, 2018

Dr. George published a new review article in collaboration with Dr. Koob that argues that characterization of the neuropsychological mechanisms that underlie individual differences in addiction-like behaviors is the key to understanding the mechanisms of addiction and...

January 9, 2018

The George lab published a new study in collaboration with the Janda lab providing preclinical evidence that a newly engineered enzyme can degrade nicotine in the blood so that nicotine cannot reach the brain and produce dependency effects.

This preclinical st...

August 26, 2017

The George lab published a new study providing preclinical evidence that several months of alcohol binge-like drinking facilitates the transition to compulsive-like alcohol drinking, but that regular drinking ultimately leads to similar level of compulsive drinking.

Thi...

May 27, 2017

The George lab published a new invited review in collaboration with Dr. Bruce Hope at the National Institute on Drugs of Abuse (NIDA) on the identification of specific neuronal ensembles responsible for different aspects of alcohol use disorder.

This review is part of a...

April 11, 2017

The George lab published a new study providing preclinical evidence that self-administration of alcohol vapor produces alcohol dependence in rats.

This preclinical study lead by Dr. de Guglielmo (Senior Research Associate in the George lab) demonstrates voluntary induct...

February 1, 2017

The George lab published a novel study providing preclinical evidence that deep brain stimulation can decrease the motivation for heroin in dependent rats.

This preclinical study lead by Dr. Wade (former postdoc in the George lab now at University of MInnesota) and in c...

September 7, 2016

The George lab published a novel study identifying a neuronal network that may be critical for alcoholism.

This preclinical study lead by Dr. De Guglielmo (postdoc in the George lab) demonstrates that the behaviors associated with alcohol dependence may be reversed by...

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Upcoming Events

Gordon Research Conference: Alcohol and the Nervous System

Dr. George will be speaking. "What's Driving Escalation of Alcohol Drinking? Evidence in Favor of the Crystallization Hypothesis"

Developing a Clearer Vision of the Integrated Neural Actions of Ethanol

Match 1-6, 2020

Galveston, TX

Gordon Research Conference: Addiction Research: From Molecules to Circuits to Treatment

Dr. George will be speaking. "The Escalation Model of Drug Addiction"

Addiction Research: From Molecules to Circuits to Treatment

August 16-21, 2020

Newry, ME

New Mexico Medical Cannabis Conference

Dr. George will be speaking. "Effect of CBD on Nicotine Dependence"

March 15, 2020

Albuquerque , NM

Research Society on Alcoholism

Dr. Kimbrough will be speaking. "Brain wide neural activation in animal models of alcohol abuse and dependence"

June 22-26th, 2019

Minneapolis, Minnesota

NeuroHIV Emerging Issues and Substance Abuse Joint Colloquium Nov 22-24th 2018

Dr. George will be speaking on "Identification of novel targets for cocaine and opioid use disorders using heterogeneous stock rats."

Outreach: Science Saturday Nov 17th 2018

Dr. George will be speaking on “Drug Wars: Episode IV – A New Hope”

Finding new therapies to fight drug addiction: The lecture will describe the effects of drugs on the brain, including alcohol, nicotine, cocaine and opioids; why some people, but not others, develop an addiction; and highlight new therapeutic strategies to fight addiction.

Scripps Research scientists and researchers bring the excitement and passion of research to middle and high school students. Every lecture highlights the cutting-edge research occurring at The Scripps Research Institute and provides a window into the life of a scientist.

"Drug Addiction & Mental Disorders" & "Impulse Control Disorders"

Dr. George is teaching PSYC 179 and PSYC188 at UCSD in Summer and Fall 2018

Summer and Fall 2018

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Building a brain map of alcohol dependence.

January 14, 2020

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