March 26, 2019

This new paper identify a key brain network responsible for alcohol dependence and demonstrates that it is possible to reverse the desire to drink in alcohol-dependent rats by targeting this specific group of neurons using lasers.

In a new study published...

October 17, 2018

The George lab demonstrates that a novel enzymatic approach that prevents nicotine from reaching the brain not only decrease the level of nicotine dependence, but also decreases compulsive nicotine intake and relapse in animal models.

In a study published online in Scie...

October 14, 2018

The George lab identified the orphan receptor GPR139 as a potential target for the treatment of compulsive alcohol drinking and hyperalgesia during alcohol withdrawal.

This study, lead by Dr. Jenni Kononoff provides 

robust preclinical evide...

July 5, 2018

The George lab, in collaboration with multiple research groups, published several studies that identify key brain mechanisms responsible for drug and nicotine addiction.

These studies 1) provide robust preclinical evidence fort the efficacy of deep brain stimu...

July 5, 2018

Dr. de Guglielmo from the George lab published a new study in collaboration with the Palmer lab (UCSD) that provide robust preclinical evidence that a novel compound called pBBG is more effective in reducing alcohol intake in dependent rats than in nondepende...

January 9, 2018

The George lab published a new study in collaboration with the Janda lab providing preclinical evidence that a newly engineered enzyme can degrade nicotine in the blood so that nicotine cannot reach the brain and produce dependency effects.

This preclinical st...

August 26, 2017

The George lab published a new study providing preclinical evidence that several months of alcohol binge-like drinking facilitates the transition to compulsive-like alcohol drinking, but that regular drinking ultimately leads to similar level of compulsive drinking.

Thi...

May 27, 2017

The George lab published a new invited review in collaboration with Dr. Bruce Hope at the National Institute on Drugs of Abuse (NIDA) on the identification of specific neuronal ensembles responsible for different aspects of alcohol use disorder.

This review is part of a...

April 11, 2017

The George lab published a new study providing preclinical evidence that self-administration of alcohol vapor produces alcohol dependence in rats.

This preclinical study lead by Dr. de Guglielmo (Senior Research Associate in the George lab) demonstrates voluntary induct...

April 14, 2015

Addiction research laboratory: Olivier George, scripps research institute, californiaTSRI Researchers Discover Neuronal Network Behind the Facilitating Effect of Nicotine on Alcohol Dependence

 

LA JOLLA, CA – March 11, 2015 – Why do smokers have a five to ten times greater risk of developing alcohol dependence than nonsmokers? Do smokers have a greater...

March 12, 2015

TSRI Researchers Discover New Mechanism that Plays Key Role in Methamphetamine Addiction

 

LA JOLLA, CA – March 11, 2015 – Methamphetamine abuse and dependence is a major issue in the US. More than 1 million people used methamphetamine in the past year and its use is ass...

November 17, 2014

TSRI Researchers Discover New Type of Neuron that Plays Key Role in Nicotine Addiction

LA JOLLA, CA – November 17, 2014 – For decades, scientists thought drug addiction was the result of two separate systems in the brain—the reward system, which was activated when a per...

August 15, 2014

A postdoctoral position will be available in the lab in a near future:

  • Succesful applicants will receive training under support from the NIH/NIAAA T32 Training grant program (US citizen/permanent residents).

  • This solicitation seeks applicants who have interest...

August 4, 2014

Latest paper published: Nicotine dependence increases the number of immature neurons in the hippocampus.

 

It was believed that nicotine and tobacco smoke decrease the production of new neurons in adult. However, previous studies have  used animal models with limited rel...

July 25, 2014

Latest paper published: A neuroanatomical, genetical, and cognitive characterization of HIV rats.

 

This paper (link to PDF) validates the use of HIV transgenic rats for the study of neuroinflammation in AIDS, and identify new pathways that could be targeted to reduce co...

Please reload

Follow Us
Upcoming Events

Research Society on Alcoholism

Dr. Kimbrough will be speaking. "Brain wide neural activation in animal models of alcohol abuse and dependence"

June 22-26th, 2019

Minneapolis, Minnesota

NeuroHIV Emerging Issues and Substance Abuse Joint Colloquium Nov 22-24th 2018

Dr. George will be speaking on "Identification of novel targets for cocaine and opioid use disorders using heterogeneous stock rats."

Outreach: Science Saturday Nov 17th 2018

Dr. George will be speaking on “Drug Wars: Episode IV – A New Hope”

Finding new therapies to fight drug addiction: The lecture will describe the effects of drugs on the brain, including alcohol, nicotine, cocaine and opioids; why some people, but not others, develop an addiction; and highlight new therapeutic strategies to fight addiction.

Scripps Research scientists and researchers bring the excitement and passion of research to middle and high school students. Every lecture highlights the cutting-edge research occurring at The Scripps Research Institute and provides a window into the life of a scientist.

"Drug Addiction & Mental Disorders" & "Impulse Control Disorders"

Dr. George is teaching PSYC 179 and PSYC188 at UCSD in Summer and Fall 2018

Summer and Fall 2018

Please reload

Featured Posts

Pilot Grants Available to use the Cocaine and Oxycodone Biobanks

June 5, 2019

1/10
Please reload