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Olivier George
- Jan 14, 2020
- 3 min
Building a brain map of alcohol dependence.
This new paper provide the first brain map of alcohol dependence at single cell resolution in an animal model of Alcohol use disorder. Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of California San Diego School of Medicine report that in an alcohol-dependent mouse model, the rodent brain’s functional architecture is substantially remodeled. But when deprived of alcohol, the mice displayed increased coordin
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Olivier George
- Jan 14, 2020
- 1 min
Treating opioid use disorder one rat at a time.
This paper provide preclinical evidence that targeting the D3 receptors may provide efficacy in the treatment of opioid use disorder. Using an animal model for the study of opioid use disorder, researchers at University of California San Diego School of Medicine report that blocking the D3 receptor using a novel and specific antagonist (VK4-116) decreases the motivation to seek and take oxycodone and decreased the negative emotional states of opioid withdrawal. The findings,
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Olivier George
- Mar 26, 2019
- 3 min
Identification of a neuronal pathway responsible for excessive drinking and alcohol dependence
This new paper identify a key brain network responsible for alcohol dependence and demonstrates that it is possible to reverse the desire to drink in alcohol-dependent rats by targeting this specific group of neurons using lasers. In a new study published online in Nature Communications on March 18, 2019, Dr. de Guglielmo used behavioral models, molecular biology, electrophysiology and optogenetics to unveil the role of a corticotropin releasing factor (CRF) neuronal ensemble
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Olivier George
- Oct 14, 2018
- 3 min
Identification of an Orphan Receptor as Novel Molecular Target for Alcohol Dependence.
The George lab identified the orphan receptor GPR139 as a potential target for the treatment of compulsive alcohol drinking and hyperalgesia during alcohol withdrawal. This study, lead by Dr. Jenni Kononoff provides robust preclinical evidence fort the efficacy of using GPR139 modulators for the treatment of alcoholism, and identify the habenula as a key brain region responsible for the therapeutic effect of GPR139 modulators. For details on the study, see the Research Highli
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Olivier George
- Jul 5, 2018
- 1 min
A novel target for the treatment of alcohol use disorder.
Dr. de Guglielmo from the George lab published a new study in collaboration with the Palmer lab (UCSD) that provide robust preclinical evidence that a novel compound called pBBG is more effective in reducing alcohol intake in dependent rats than in nondependent rats. Previous studies showed that the glyoxalase 1 (Glo1) gene modulates anxiety-like behavior, seizure susceptibility, depression-like behavior, and alcohol drinking in the drinking-in-the-dark paradigm in nondepende
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