A key aspect of treating drug abuse is understanding similarities and differences of how drugs of abuse affect the brain. The George Lab published a new study investigating how the brain is altered during withdrawal from psychostimulants. Using single-cell whole-brain imaging in mice, we found that each drug produced a unique pattern of activity in the brain, but that brains in withdrawal from cocaine and methamphetamine shared similar features. Interestingly, we found the m

The George Lab published a new study investigating electronic cigarette use. The main goal of the study was to validate a new pre-clinical model of nicotine vapor self-administration with anatomical and behavioral characterization of dependence. We examined the effects of chronic nicotine vapor intake on key behaviors that are related to nicotine withdrawal in male and female rats, including hyperalgesia, somatic signs, and anxiety-like behavior. Our data showed that two wee

Our newest review, “Role of CRF in Alcohol and Nicotine Addiction” was recently published in a special collection on "The Role of...