Opioid use disorder (OUD) has grown into a severe global health emergency, yet long term abstinence remains an elusive goal for many. One major reason is that chronic opioid use leaves lasting marks on the brain that persist long after someone stops using. In our latest study, we used advanced genetic sequencing to compare the molecular changes in the human brain with those in animal models to find common "signatures" of addiction. The Big Question We wanted to know if the ch

In our latest review paper, we explore the deep biological links between stress and nicotine addiction. This work is especially meaningful as it is dedicated to the honor of Dr. Klaus Miczek, a true pioneer in the field who recently passed away. I personally loved interacting with him, and his groundbreaking work on the neurobiology of social stress continues to inspire our research. The Big Question We wanted to synthesize how stress, particularly social defeat stress, acts

We often hear that nicotine is a powerful appetite suppressant. This is why many long term smokers find it difficult to quit, fearing the weight gain that often follows. However, our recent study has uncovered a fascinating paradox: while nicotine might help keep weight off in the long run, an acute dose of nicotine actually makes some individuals want to eat more right away. The Big Question We set out to investigate why nicotine has these two opposite effects on feeding beh