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Olivier George
- Jul 5, 2018
- 1 min
A novel target for the treatment of alcohol use disorder.
Dr. de Guglielmo from the George lab published a new study in collaboration with the Palmer lab (UCSD) that provide robust preclinical evidence that a novel compound called pBBG is more effective in reducing alcohol intake in dependent rats than in nondependent rats. Previous studies showed that the glyoxalase 1 (Glo1) gene modulates anxiety-like behavior, seizure susceptibility, depression-like behavior, and alcohol drinking in the drinking-in-the-dark paradigm in nondepende
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Olivier George
- Oct 17, 2012
- 1 min
Alcohol binge drinking
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Science of the United States of America. Olivier George, Chelsea Sanders, John Freiling, Edward Grigoryan, Shayla Vu, Camryn D. Allen, Elena Crawford, Chitra D. Mandyam, and George F. Koob "The researchers linked the rats’ impairment to a small group of brain cells, or neurons, in the prefrontal cortex
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