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Olivier George
- Jan 13, 2020
- 2 min
Identification of a new target that reduces excessive opioid use in dependent individuals.
This new paper identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates that it is possible to reverse the motivation to use opioids in opioid-dependent rats. More than 2 million individuals in the United States currently have a substance use disorder that is related to prescription opioid pain relievers. In a new study published online in PNSA on January 13, 2020, Drs. Kallupi and de Guglielmo used behavioral models, mol
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Olivier George
- Jul 5, 2018
- 2 min
Identification of the cellular mechanisms of drug and nicotine addiction.
The George lab, in collaboration with multiple research groups, published several studies that identify key brain mechanisms responsible for drug and nicotine addiction. These studies 1) provide robust preclinical evidence fort the efficacy of deep brain stimulation of the subthalamic nucleus in cocaine addiction, 2) double dissociate the role of the dorsal and ventral serotoninergic systems in cocaine intake, 3) provide a mechanism to explain the reducing effect of nicotine
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