Dynorphin system and heroin escalation

Long-term antagonism of kappa opioid receptors preventsescalation of and increased motivation for heroin intake.

Journal of Neuroscience. in press

Schlosburg J, Whitfield T, Park P, Crawford E, George O, Vendruscolo L, and Koob GF

#heroin #dynorphin #stress #accumbens #kappa #craving

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