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Olivier George
- Jul 29, 2015
- 1 min
Our work on nicotine dependence featured in Nature Outlook.
Increasing awareness of the dramatic impact of drug addiction on our society and providing novel therapeutic approaches to cure drug addiction are key missions of TSRI researchers in the George lab. LA JOLLA, CA – July 29 2015 – Nature Outlook: Addiction is a very interesting and free full access supplement aimed at the general public which describe the impact of drug addiction on our society and highlight the latest researchs and theories on drug addiction. Our work on nicot
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Olivier George
- Jul 6, 2015
- 1 min
A novel therapeutic strategy for alcoholism: Blocking the stress system using glucocorticoid antagon
A new paper published in collaboration with Leandro Vendruscolo and the Barbara Mason lab provide robust evidence that mifepristone reduces alcohol drinking in rats and humans. LA JOLLA, CA – April 21, 2015 – The present studies indicate that attenuation of GR function by mifepristone reduces compulsive-like alcohol intake in alcohol-dependent rats and reduces both excessive drinking and alcohol craving in recently abstinent alcoholics — in addition to improving liver-functio
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Olivier George
- Apr 14, 2015
- 3 min
New paper published: Nicotine facilitates the transition to alcohol dependence through dysfunction o
LA JOLLA, CA – March 11, 2015 – Why do smokers have a five to ten times greater risk of developing alcohol dependence than nonsmokers? Do smokers have a greater tendency toward addiction in general or does nicotine somehow reinforce alcohol consumption? Now, a study led by scientists at The Scripps Research Institute (TSRI) helps provide insight into these questions, showing that, in rat models, nicotine exposure actually promotes alcohol dependence. "It's a vicious cycle," s
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Olivier George
- Mar 12, 2015
- 3 min
New paper published: Finding new ways to treat methamphetamine dependence.
LA JOLLA, CA – March 11, 2015 – Methamphetamine abuse and dependence is a major issue in the US. More than 1 million people used methamphetamine in the past year and its use is associated with dramatic health effects and cost the nation >20 billions dollars per year. Unfortunately, there is no FDA-approved medications to help prevent methamphetamine addiction. Now scientists at The Scripps Research Institute (TSRI) have found that targeting a specific neurotransmitter system
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Olivier George
- Dec 14, 2013
- 1 min
Dynorphin system and heroin escalation
Long-term antagonism of kappa opioid receptors preventsescalation of and increased motivation for heroin intake. Journal of Neuroscience. in press Schlosburg J, Whitfield T, Park P, Crawford E, George O, Vendruscolo L, and Koob GF #heroin #dynorphin #stress #accumbens #kappa #craving
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Olivier George
- Jul 17, 2013
- 1 min
CRF, anxiety, pain and nicotine dependence
Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 2013 Jul 22 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. #addiction #craving #nicotine #escalation #crf #pain #anxiety #amygdala #stress
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Olivier George
- Jun 17, 2013
- 1 min
Addiction and stress
Addiction as a stress surfeit disorder Neuropharmacology. 2013 Jun 6 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O #addiction #stress #amygdala #craving #escalation #impulsivity #compulsivity
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