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Olivier George
- Nov 12, 2017
- 1 min
SFN2017 here we come!
The George lab will be presenting its latest research at SFN 2017. Come meet us on Wednesday 15th, Halls A-C, QQ5-QQ10. Meet Drs. de Guglielmo, Kallupi, Kimbrough, Kononnoff, and Ms Simpson and Maturin. 793.01 - CRF neurons in the central nucleus of the amygdala that project to the bed nucleus of the stria terminalis drive excessive alcohol drinking in dependent rats. 793.02 / QQ6 - The Cocaine Biobank: A repository of biological samples from genetically characterized outbred
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Olivier George
- May 27, 2017
- 1 min
Cortical and Amygdalar Neuronal Ensembles in Alcohol Seeking, Drinking and Withdrawal
The George lab published a new invited review in collaboration with Dr. Bruce Hope at the National Institute on Drugs of Abuse (NIDA) on the identification of specific neuronal ensembles responsible for different aspects of alcohol use disorder. This review is part of a special issue of Neuropharmacology edited by Dr. Adron R. Harris (University of Texas at Austin) and Dr. George F, Koob (NIH/NIAAA) on the Neuropharmacology of Alcoholism. Article on the Neuropharmacology's we
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Olivier George
- Jan 11, 2016
- 1 min
Interested in a paid Summer Research Internship?
Apply now to join the George Lab this summer and get paid during your internship! The National Institute on Drug Abuse (NIDA) invites high school and undergraduate students interested in pursuing a career in science to submit applications for the 2016 NIDA Summer Research Program. To apply and for complete program information, see the online application form.
· Interns work with NIDA funded scientists at research institutions across the United States for 8 weeks i
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Olivier George
- Jul 6, 2015
- 1 min
A novel therapeutic strategy for alcoholism: Blocking the stress system using glucocorticoid antagon
A new paper published in collaboration with Leandro Vendruscolo and the Barbara Mason lab provide robust evidence that mifepristone reduces alcohol drinking in rats and humans. LA JOLLA, CA – April 21, 2015 – The present studies indicate that attenuation of GR function by mifepristone reduces compulsive-like alcohol intake in alcohol-dependent rats and reduces both excessive drinking and alcohol craving in recently abstinent alcoholics — in addition to improving liver-functio
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Olivier George
- Apr 22, 2015
- 1 min
New paper published in collaboration with the Tapper lab: Identification of a new brain pathway cont
LA JOLLA, CA – April 21, 2015 – Few months ago we published a paper in Nature Neuroscience providing evidence that a previously unknown population of corticotropin releasing factor (CRF) neurons in the ventral tegmental area (VTA) was responsible for the emergence of nicotine withdrawal and excessive nicotine intake observed in dependent mice and rats. One important question which was left unanswered in the previous study was "Where do these VTA CRF neurons projects to? The p
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Olivier George
- Apr 14, 2015
- 3 min
New paper published: Nicotine facilitates the transition to alcohol dependence through dysfunction o
LA JOLLA, CA – March 11, 2015 – Why do smokers have a five to ten times greater risk of developing alcohol dependence than nonsmokers? Do smokers have a greater tendency toward addiction in general or does nicotine somehow reinforce alcohol consumption? Now, a study led by scientists at The Scripps Research Institute (TSRI) helps provide insight into these questions, showing that, in rat models, nicotine exposure actually promotes alcohol dependence. "It's a vicious cycle," s
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Olivier George
- Mar 12, 2015
- 3 min
New paper published: Finding new ways to treat methamphetamine dependence.
LA JOLLA, CA – March 11, 2015 – Methamphetamine abuse and dependence is a major issue in the US. More than 1 million people used methamphetamine in the past year and its use is associated with dramatic health effects and cost the nation >20 billions dollars per year. Unfortunately, there is no FDA-approved medications to help prevent methamphetamine addiction. Now scientists at The Scripps Research Institute (TSRI) have found that targeting a specific neurotransmitter system
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Olivier George
- Nov 17, 2014
- 4 min
New paper published by the George Lab: Identification of a new type of neurons that contributes to n
TSRI Researchers Discover New Type of Neuron that Plays Key Role in Nicotine Addiction LA JOLLA, CA – November 17, 2014 – For decades, scientists thought drug addiction was the result of two separate systems in the brain—the reward system, which was activated when a person used a drug, and the stress system, which kicked in during withdrawal. Now scientists at The Scripps Research Institute (TSRI) have found that these two systems are actually linked. Their findings, publishe
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Olivier George
- Aug 4, 2014
- 1 min
Smoking may produce excessive immature neurons
Latest paper published: Nicotine dependence increases the number of immature neurons in the hippocampus. It was believed that nicotine and tobacco smoke decrease the production of new neurons in adult. However, previous studies have used animal models with limited relevance to nicotine dependence such as limited access to nicotine self-administration or passive exposure to nicotine of tobacco smoke. New results from the George and Mandyam labs (link to PDF), using a novel an
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Olivier George
- May 7, 2014
- 1 min
Exploring the Brain Milky Way
12 million light years separate these two pictures. On the right is a picture of Orphan stars that don't belong to any galaxy, discovered by the Hubble telescope in 2008. On the left is one of our latest picture of a new population of neurons that don't belong to any textbook. After 5 years of work we finally have rock solid evidence that these new neurons exist in mice, rats and even human. The most unexplored territories are within ourselves. Big thanks to Molly Brennan and
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