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Olivier George
- Jan 14, 2020
- 3 min
Building a brain map of alcohol dependence.
This new paper provide the first brain map of alcohol dependence at single cell resolution in an animal model of Alcohol use disorder. Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of California San Diego School of Medicine report that in an alcohol-dependent mouse model, the rodent brain’s functional architecture is substantially remodeled. But when deprived of alcohol, the mice displayed increased coordin
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Olivier George
- Jan 14, 2020
- 1 min
Treating opioid use disorder one rat at a time.
This paper provide preclinical evidence that targeting the D3 receptors may provide efficacy in the treatment of opioid use disorder. Using an animal model for the study of opioid use disorder, researchers at University of California San Diego School of Medicine report that blocking the D3 receptor using a novel and specific antagonist (VK4-116) decreases the motivation to seek and take oxycodone and decreased the negative emotional states of opioid withdrawal. The findings,
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Olivier George
- Jan 13, 2020
- 2 min
Identification of a new target that reduces excessive opioid use in dependent individuals.
This new paper identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates that it is possible to reverse the motivation to use opioids in opioid-dependent rats. More than 2 million individuals in the United States currently have a substance use disorder that is related to prescription opioid pain relievers. In a new study published online in PNSA on January 13, 2020, Drs. Kallupi and de Guglielmo used behavioral models, mol
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Olivier George
- Mar 26, 2019
- 3 min
Identification of a neuronal pathway responsible for excessive drinking and alcohol dependence
This new paper identify a key brain network responsible for alcohol dependence and demonstrates that it is possible to reverse the desire to drink in alcohol-dependent rats by targeting this specific group of neurons using lasers. In a new study published online in Nature Communications on March 18, 2019, Dr. de Guglielmo used behavioral models, molecular biology, electrophysiology and optogenetics to unveil the role of a corticotropin releasing factor (CRF) neuronal ensemble
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Olivier George
- Jan 9, 2018
- 1 min
An enzymatic advance in nicotine cessation therapy.
The George lab published a new study in collaboration with the Janda lab providing preclinical evidence that a newly engineered enzyme can degrade nicotine in the blood so that nicotine cannot reach the brain and produce dependency effects. This preclinical study co-lead by Dr. Xue (Research Associate in the Janda lab) and Dr. Kallupi (Research Associate in the George lab) shows that administration of this new enzyme called NicA2 can prevent the development of nicotine depend
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Olivier George
- Aug 26, 2017
- 2 min
Alcohol binge-drinking facilitates the transition to dependence, but regular drinking may be almost
The George lab published a new study providing preclinical evidence that several months of alcohol binge-like drinking facilitates the transition to compulsive-like alcohol drinking, but that regular drinking ultimately leads to similar level of compulsive drinking. This preclinical study lead by Dr. Adam Kimbrough (Research Associate in the George lab) shows that in rats, 5 months of prior intermittent, but not continuous, access to ethanol, accelerated the transition to exc
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Olivier George
- May 27, 2017
- 1 min
Cortical and Amygdalar Neuronal Ensembles in Alcohol Seeking, Drinking and Withdrawal
The George lab published a new invited review in collaboration with Dr. Bruce Hope at the National Institute on Drugs of Abuse (NIDA) on the identification of specific neuronal ensembles responsible for different aspects of alcohol use disorder. This review is part of a special issue of Neuropharmacology edited by Dr. Adron R. Harris (University of Texas at Austin) and Dr. George F, Koob (NIH/NIAAA) on the Neuropharmacology of Alcoholism. Article on the Neuropharmacology's we
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Olivier George
- Apr 11, 2017
- 3 min
Voluntary vaping alcohol produces alcohol dependence in rats.
The George lab published a new study providing preclinical evidence that self-administration of alcohol vapor produces alcohol dependence in rats. This preclinical study lead by Dr. de Guglielmo (Senior Research Associate in the George lab) demonstrates voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. This study is groundbreaking for two reasons. The first is because it shows that vaping alcohol, a new trend in adolesc
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Olivier George
- Jul 29, 2015
- 1 min
Our work on nicotine dependence featured in Nature Outlook.
Increasing awareness of the dramatic impact of drug addiction on our society and providing novel therapeutic approaches to cure drug addiction are key missions of TSRI researchers in the George lab. LA JOLLA, CA – July 29 2015 – Nature Outlook: Addiction is a very interesting and free full access supplement aimed at the general public which describe the impact of drug addiction on our society and highlight the latest researchs and theories on drug addiction. Our work on nicot
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Olivier George
- Jul 6, 2015
- 1 min
A novel therapeutic strategy for alcoholism: Blocking the stress system using glucocorticoid antagon
A new paper published in collaboration with Leandro Vendruscolo and the Barbara Mason lab provide robust evidence that mifepristone reduces alcohol drinking in rats and humans. LA JOLLA, CA – April 21, 2015 – The present studies indicate that attenuation of GR function by mifepristone reduces compulsive-like alcohol intake in alcohol-dependent rats and reduces both excessive drinking and alcohol craving in recently abstinent alcoholics — in addition to improving liver-functio
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Olivier George
- Apr 22, 2015
- 1 min
New paper published in collaboration with the Tapper lab: Identification of a new brain pathway cont
LA JOLLA, CA – April 21, 2015 – Few months ago we published a paper in Nature Neuroscience providing evidence that a previously unknown population of corticotropin releasing factor (CRF) neurons in the ventral tegmental area (VTA) was responsible for the emergence of nicotine withdrawal and excessive nicotine intake observed in dependent mice and rats. One important question which was left unanswered in the previous study was "Where do these VTA CRF neurons projects to? The p
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