Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats.

Addiction Biology. 2013 Jul 22

Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O.

#addiction #craving #nicotine #escalation #crf #pain #anxiety #amygdala #stress