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Olivier George
- Jan 14, 2020
- 3 min
Building a brain map of alcohol dependence.
This new paper provide the first brain map of alcohol dependence at single cell resolution in an animal model of Alcohol use disorder. Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of California San Diego School of Medicine report that in an alcohol-dependent mouse model, the rodent brain’s functional architecture is substantially remodeled. But when deprived of alcohol, the mice displayed increased coordin
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Olivier George
- Jan 13, 2020
- 2 min
Identification of a new target that reduces excessive opioid use in dependent individuals.
This new paper identify a neuropeptide that is acting in a key brain region responsible for opioid dependence and demonstrates that it is possible to reverse the motivation to use opioids in opioid-dependent rats. More than 2 million individuals in the United States currently have a substance use disorder that is related to prescription opioid pain relievers. In a new study published online in PNSA on January 13, 2020, Drs. Kallupi and de Guglielmo used behavioral models, mol
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Olivier George
- Mar 26, 2019
- 3 min
Identification of a neuronal pathway responsible for excessive drinking and alcohol dependence
This new paper identify a key brain network responsible for alcohol dependence and demonstrates that it is possible to reverse the desire to drink in alcohol-dependent rats by targeting this specific group of neurons using lasers. In a new study published online in Nature Communications on March 18, 2019, Dr. de Guglielmo used behavioral models, molecular biology, electrophysiology and optogenetics to unveil the role of a corticotropin releasing factor (CRF) neuronal ensemble
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Olivier George
- Jul 17, 2013
- 1 min
CRF, anxiety, pain and nicotine dependence
Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 2013 Jul 22 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. #addiction #craving #nicotine #escalation #crf #pain #anxiety #amygdala #stress
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Olivier George
- Jun 17, 2013
- 1 min
Addiction and stress
Addiction as a stress surfeit disorder Neuropharmacology. 2013 Jun 6 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O #addiction #stress #amygdala #craving #escalation #impulsivity #compulsivity
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Olivier George
- May 5, 2013
- 1 min
NPY, anxiety and alcohol
Neuropeptide Y Y2 R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats Addiction BIology. 2013 May 3 Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW #alcohol #amygdala #anxiety #npy
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Olivier George
- Oct 17, 2012
- 1 min
Alcohol binge drinking
Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Science of the United States of America. Olivier George, Chelsea Sanders, John Freiling, Edward Grigoryan, Shayla Vu, Camryn D. Allen, Elena Crawford, Chitra D. Mandyam, and George F. Koob "The researchers linked the rats’ impairment to a small group of brain cells, or neurons, in the prefrontal cortex
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